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Canonical PRC1 influences gross nuclear organization. (A) PcG mediated interactions occur preferentially between sites with the most pronounced and extended domains of canonical PRC1 occupancy. (B) We propose that PRC1-bound loci cluster together in the nucleus to form discrete polycomb bodies. This clustering, coupled with the polymeric nature of chromatin, imposes topological constraint on intervening non-PcG-associated portion of the genome.
