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. 2020 Jul 1;288:198082. doi: 10.1016/j.virusres.2020.198082

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© 2020 The Authors

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 1 — The locations of the 34 non-allergenic and non-toxic linear B-cell epitopes in the 3D structure of SARS-CoV-2 S protein (PDB ID 6VSB). (A-B) The locations of the 24 non-allergenic and non-toxic B-cell epitopes in the spike stem region; (C) The locations of the ten non-allergenic and non-toxic B-cell epitopes in the spike head which is the most exposed region. (D) The locations of the ten linear non-allergenic and non-toxic B-cell epitopes mapped to the predicted interacting conformation between the RBD domain of SARS-CoV-2 S protein and ACE-2. From A to C, Green, cyan and purple are chain A, chain B and chain C, respectively; Blue, red and pink are the locations of the 34 non-allergenic and non-toxic linear B-cell epitopes in chain A, chain B, and chain C, respectively. In D, light green is the ACE-2; Grey is the RBD of S protein; Light red is the locations of the ten non-allergenic and non-toxic B-cell epitopes in RBD.