Fig. 4.

Conservation of B- and T-cell epitopes in SARS-CoV-2. The position of conserved epitopes in the protein sequence. (A) S protein, (B) M protein, (C) N protein. The e colored by orange is exposed residues according to the neural-network algorithm; the b colored by green is buried residues according to the neural-network algorithm; the f colored by red is predicted functional residue (highly conserved and exposed); the s colored by dark blue is predicted structural residues (highly conserved and buried). The conservation scale represents the status of conversation from variable, average to convserved. (D) The mutations observed in the ten non-allergenic and non-toxic linear B-cell epitopes in the RBD. Brown, yellow and light brown represent chain A, chain B and chain C. Red represent the locations of the ten non-allergenic and non-toxic linear B-cell epitopes in RBD region; blue represent the observed mutations. The black AAs in the epitopes are the mutated ones.