Table 5.
Elevated anti-neuronal autoantibody ELISA titers were associated with positive CaMKII activation in disease subjects but not in healthy controls.
| Autoantigen |
PANDAS Sera Dual Positive w/CaMKII (Table 1) |
PANDAS CSF Dual Positive w/CaMKII (Table 2) |
Healthy Subjects Dual Positive w/CaMKII (Table 3) |
|||
|---|---|---|---|---|---|---|
| # | %* | # | %* | # | %* | |
| Anti-D1R | 19/25 | 76% | 6/10 | 60% | 0/4 | 0% |
| Anti-D2R | 8/9 | 89% | 15/22 | 68% | 0/4 | 0% |
| Anti-lysoganglioside-GM1 | 5/6 | 83% | 1/2 | 50% | 0/1 | 0% |
| Anti-tubulin | 8/10 | 80% | 3/4 | 75% | 0/1 | 0% |
*Percent CaMKII positive
PANDAS, pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections; D1R, dopamine receptor D1; D2R, dopamine receptor D2L; CaMKII, calcium/calmodulin-dependent protein kinase, positive ≥130 for sera, ≥100 for CSF.