Table 1.
Overview of data extraction of the included systematic reviews regarding plaque index scores and gingival index
| Source | Index | Outcomes | Heterogeneitya | |||||
|---|---|---|---|---|---|---|---|---|
| Ingredient | Systematic review | No. experiments in meta‐analysis | DiffM | 95% CI | P value | I 2, % | P value* | |
| Plaque index | ||||||||
| Dentifrice | Valkenburg et al23 | 18 | Q&H28 | 0.00 | −0.05; 0.05 | .91 | 0 | .57 |
| CHX | Serrano et al25 | 4 | Q&H Turesky28 | −0.687 | −1.317; −0.057 | .000 | 97.4 | .000 |
| CHX | Escribano et al29 | 3 | Q&H Turesky28 | −0.81 | −1.74; 0.12 | .09 | 98.2 | ? |
| SnF | Paraskevas and Van der Weijden36 | 4 | Q&H Turesky28 | −0.31 | −0.54; −0.07 | .01 | 91.7 | <.0001 |
| SnF | Gunsolley24 | 5 | Q&H28 | −0.168■ | ? | .007 | ? | ? |
| SnF | Serrano et al25 | 3 | Q&H Turesky28 | −0.112 | −0.185; 0.040 | .002 | 61.4 | .062 |
| SnF | Escribano et al29 | 5 | Q&H Turesky28 | −0.28 | −0.49; −0.07 | .01 | 90.7 | ? |
| Triclosan‐COP | Serrano et al25 | 18 | Q&H Turesky28 | −0.447 | −0.594; −0.300 | .000 | 95.4 | .000 |
| Triclosan‐COP | Escribano et al29 | 16 | Q&H Turesky28 | −0.49 | −0.60; −0.28 | .00 | 94.2 | ? |
| Triclosan‐COP | Hioe and Van der Weijden35 | 9 | Q&H Turesky28 | −0.48 | −0.73; −0.24 | <.0001 | 97.2 | <.00001 |
| Triclosan‐COP | Davies et al37 | 15 | Q&H28 | −0.48 | −0.64; −0.32 | <.00001 | 95.7 | <.00001 |
| Triclosan‐COP | Riley and Lamont79 | 20 | Q&H28 | −0.47 | −0.60; −0.34 | <.00001 | 94 | <.00001 |
| Triclosan‐COP | Gunsolley24 | 18 | Q&H Turesky28 | −0.823■ | ? | <.00 | ? | ? |
| Triclosan‐ZnCIT | Gunsolley24 | 2 | Q&H Turesky28 | ? | ? | .551 | ? | ? |
| Triclosan‐PYRO | Gunsolley24 | 4 | Q&H Turesky28 | ? | ? | .040 | ? | ? |
| Triclosan‐COP | Serrano et al25 | 3 | S&L32 | −0.139 | −0.371; 0.094 | .242 | 96.7 | .000 |
| Triclosan‐COP | Riley and Lamont79 | 2 | L&S31 | −0.05 | −0.10; −0.01 | .027 | 8 | .30 |
| Triclosan‐ZnCIT | Hioe and Van der Weijden35 | 6 | S&L32 | −0.07 | −0.10; −0.05 | <.00001 | 0 | .53 |
| Triclosan‐ZnCIT | Serrano et al25 | 6 | S&L32 | −0.095 | −0.186; −0.005 | .000 | 89.2 | .000 |
| Triclosan‐PYRO | Serrano et al25 | 2 | S&L32 | −0.002 | −0.056; 0.060 | .953 | 0 | .739 |
| SnF vs triclosan | Sälzer et al10 | 7 | Q&H28 | −0.29 | −0.45; −0.13 | <.001 | 90 | <.001 |
| 4 | RMNPI33 | 0.09 | −0.01; 0.18 | .07 | 97 | <.001 | ||
| Gingival index | ||||||||
| CHX | Serrano et al25 | 4 | L&S31 | −0.289 | −0.558; −0.021 | .000 | 92.8 | .000 |
| SnF | Paraskevas and Van der Weijden36 | 6 | L&S31 | −0.15 | −0.20; −0.11 | <.00001 | 91.1 | <.00001 |
| SnF | Gunsolley24 | 6 | L&S31 | −0.441■ | ? | .000 | ? | .010 |
| SnF | Serrano et al25 | 2 | L&S31 | −0.115 | −0.161; −0.069 | .000 | 64.8 | .092 |
| SnF AMIN | Serrano et al25 | 2 | L&S31 | −0.059 | −0.074; −0.044 | .000 | 26.5 | .243 |
| Triclosan‐COP | Serrano et al25 | 16 | L&S31 | −0.241 | −0.304; −0.178 | .000 | 91.2 | .000 |
| Triclosan‐COP | Hioe and Van der Weijden35 | 8 | L&S31 | −0.24 | −0.35; −0.13 | <.0001 | 98.3 | <.00001 |
| Triclosan‐COP | Davies et al37 | 14 | L&S31 | −0.26 | −0.34; −0.18 | <.00001 | 96.5 | <.00001 |
| Triclosan‐COP | Riley and Lamont79 | 20 | L&S31 | −0.27 | −0.33; −0.21 | <.00001 | 95 | <.00001 |
| Triclosan‐COP | Gunsolley24 | 16 | L&S31 | −0.858■ | ? | .000 | ? | <.001 |
| Triclosan‐PYRO | Gunsolley24 | 3 | L&S31 | ? | ? | .647 | ? | ? |
| SnF | Gunsolley24 | 2 | MGI80 | ? | ? | .000 | ? | ? |
| SnF‐HEXA | Serrano et al25 | 2 | MGI80 | −0.382 | −0.449; −0.315 | .000 | 60.3 | .112 |
| SnF‐SHMP | Serrano et al25 | 2 | BOP81 | −4.666 | −6.984; −2.347 | .000 | 82.5 | .017 |
| Triclosan‐COP | Serrano et al25 | 2 | BOP81 | −3.153 | −9.128; 2.821 | .301 | 65.8 | .087 |
| Triclosan‐PYRO | Serrano et al25 | 2 | BOP81 | −4.344 | −12.366; 3.677 | .288 | 77.4 | .036 |
| Triclosan‐ZnCIT | Hioe and Van der Weijden35 | 4 | BOP81 | −10.81 | −12.69; −8.93 | <.00001 | 0 | .48 |
| ZnCIT | Serrano et al25 | 5 | BOP81 | −9.301 | −12.875; −5.727 | .000 | 76.8 | .002 |
| SnF vs triclosan | Sälzer et al10 | 14 | L&S31 | −0.04 | −0.11; 0.04 | .34 | 97 | <.001 |
| 7 | GBI82 | 0.02 | 0.01; 0.03 | <.001 | 67 | .01 | ||
BOP, bleeding on probing81; CHX, chlorhexidine; COP, copolymer; GBI, Gingival Bleeding Index82; L&S, Loë‐Silness gingivitis index31; MGI, Modified Gingival Index80; RMNPI, Rustogi Modification of Navy Plaque Index33; S&L, Silness‐Löe plaque index32; SnF, stannous fluoride; Q&H, Quigley and Hein plaque index28; ZnCIT, zinc citrate; ?: unknown; ■: standardized mean difference; PYRO, pyrophosphates; AMIN, amin fluoride; HEXA, hexametaphosphate; SHMP, sodium hexametaphosphate.
*P value > 0.1 not significant.
Heterogeneity within the meta‐analysis can be tested by chi‐squared test and I 2 statistic. A chi‐squared test resulting in P < 0.1 was considered an indication of significant statistical heterogeneity. As a rough guide for assessing the possible magnitude of inconsistency across studies, an I 2 statistic of 0%‐40% can be interpreted as not important; above 40% moderate (40%‐80%) to considerable (>80%) heterogeneity may be present.83