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. 2020 Jun 30;8(1):e000381. doi: 10.1136/jitc-2019-000381

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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GMS in MSK training and internal validation cohort of patients with non-squamous NSCLC treated with anti-PD-(L)1 based immunotherapy. (A) Survminer R package determine the optimal cut-point to separate patients into GMS-high and GMS-low groups based on GMS score and progression-free survival in the training cohort. Kaplan-Meier estimates of (B) progression-free survival and (C) overall survival according to GMS status in MSK training cohort. Kaplan-Meier estimates of (D) progression-free survival and (E) overall survival according to GMS status in MSK internal validation cohort. GMS, genomic mutation signature; MSK, Memorial Sloan Kettering; NSCLC, non-small cell lung cancer.