Table 3.

Univariate and multivariable Cox regression analysis of progression-free survival in three anti-PD-(L)1 treated cohorts with valid TMB, PD-L1, and GMS data (n=156)

Variable	Univariate analysis			Multivariate analysis
	HR	95% CI	P value	HR	95% CI	P value
GMS (high vs low)	0.29	0.18 to 0.45	<0.001	0.30	0.19 to 0.49	<0.001
TMB (high vs low)	0.43	0.30 to 0.63	<0.001
PD-L1 (≥1% vs <1%)	0.53	0.36 to 0.76	0.001	0.64	0.44 to 0.93	0.020
Gender (male vs female)	0.92	0.60 to 1.40	0.691
Age (≥65 vs <65 years)	1.07	0.75 to 1.52	0.721
Smoking (ever vs never)	0.56	0.37 to 0.84	0.006

The p values in bold were statistically significant.

CI, confidence interval; GMS, genomic mutation signature; HR, hazard ratio; PD-L1, programmed cell death ligand 1; TMB, tumor mutation burden.