Extended Data Table 3:

Critical human ACE2-binding residues in SARS-CoV-2 and SARS-CoV RBDs.

Viral RBD	Year	442	468-471	472	479	480	487
SARS-human	2002	Y	P-PA	L	N	D	T
SARS-civet	2002	Y	P-PA	L	K	D	S
CoV-pangolin/GD	2020	L (455)	GVEG (482-485)	F(486)	Q (493)	S (494)	N (501)
CoV-pangolin/GX	2020	L (455)	GQVG (482-485)	L (486)	E (493)	R (494)	T (501)
Rs3367-bat	2013	S (443)	P-PA (469-472)	F (473)	N (480)	D (481)	N (488)
RaTG13-bat	2020	L (455)	GQTG (482-485)	L (486)	Y (493)	R (494)	D (501)
SARS-CoV-2	2019	L (455)	GVEG (482-485)	F (486)	Q (493)	S (494)	N (501)