Skip to main content
. 2020 Jul 1;15(7):e0235143. doi: 10.1371/journal.pone.0235143

Fig 2. Subclassification of amyloidosis by immunohistochemistry of major amyloid proteins.

Fig 2

The Immunohistochemical results of serum amyloid A (SAA), transthyretin (TTR), immunoglobulin kappa light chain (IGK), immunoglobulin lambda light chain (IGL), and beta-2-macroglobulin (B2M) were evaluated with a four-tiered scales (0 to 3+). The scales are presented in white, and light, intermediate, and dark orange. Note the boxes delineated in red show three sets of cases that did not meet the criteria for subclassification: (1) only one section available (#12 and #13), (2) no 3+ immunostaining (#22 and #23), and (3) 3+ and 2+ immunostaining in each pair (#17 and #24). AA, AA amyloidosis; AB2M, beta-2-macroglobulin amyloidosis; ALκ, amyloid light chain (kappa) amyloidosis; ALλ, amyloid light chain (lambda) amyloidosis; ATTR, ATTR amyloidosis; N, subclassification could not be determined at autopsy; N/A, tissues not available.