Table 1.
Baseline Characteristics of Normal Enzyme vs Single Disaccharidase Enzyme Deficient vs Pan-disaccharidase Enzyme Deficient Patients
| Characteristics | Total (N = 120 [100.0%]) | Normal (n = 64 [53.3%]) | Pan-disaccharidase (n = 11 [9.2%]) | Single deficiency (n = 45 [37.5%])a | Raw P-value | Bonferroni adjustment |
|---|---|---|---|---|---|---|
| Gender | 0.478 | |||||
| Female | 83 (69.2) | 44 (68.8) | 6 (54.6) | 33 (73.3) | ||
| Male | 37 (30.8) | 20 (31.3) | 5 (45.5) | 12 (26.7) | ||
| Pain | 0.027 | 0.324 | ||||
| Yes | 93 (77.5) | 51 (79.7) | 5 (45.5) | 37 (82.2) | ||
| No | 27 (22.5) | 13 (20.3) | 6 (54.6) | 8 (17.8) | ||
| Cramping | 0.012 | 0.144 | ||||
| Yes | 71 (59.2) | 42 (65.6) | 2 (18.2) | 27 (60.0) | ||
| No | 49 (40.8) | 22 (34.4) | 9 (81.8) | 18 (40.0) | ||
| Bloating | 0.838 | > 0.99 | ||||
| Yes | 99 (82.5) | 54 (84.4) | 9 (81.8) | 36 (80.0) | ||
| No | 21 (17.5) | 10 (15.6) | 2 (18.2) | 9 (20.0) | ||
| Fullness | 0.030 | 0.360 | ||||
| Yes | 85 (70.8) | 47 (73.4) | 4 (36.4) | 34 (75.6) | ||
| No | 35 (29.2) | 17 (26.6) | 7 (63.6) | 11 (24.4) | ||
| Nausea | 0.070 | 0.840 | ||||
| Yes | 69 (57.5) | 41 (64.1) | 3 (27.3) | 25 (55.6) | ||
| No | 51 (42.5) | 23 (35.9) | 8 (72.7) | 20 (44.4) | ||
| Belching | 0.050 | 0.600 | ||||
| Yes | 61 (50.8) | 37 (57.8) | 2 (18.2) | 22 (48.9) | ||
| No | 59 (49.2) | 27 (42.2) | 9 (81.8) | 23 (51.1) | ||
| Indigestion | 0.003 | 0.036 | ||||
| Yes | 69 (57.5) | 41 (64.1) | 1 (9.1) | 27 (60.0) | ||
| No | 51 (42.5) | 23 (35.9) | 10 (90.9) | 18 (40.0) | ||
| Diarrhea | 0.071 | 0.852 | ||||
| Yes | 71 (59.2) | 41 (64.1) | 3 (27.3) | 27 (60.0) | ||
| No | 49 (40.8) | 23 (35.9) | 8 (72.7) | 18 (40.0) | ||
| Gas | 0.053 | 0.636 | ||||
| Yes | 90 (75.0) | 51 (79.7) | 5 (45.5) | 34 (75.6) | ||
| No | 30 (25.0) | 13 (20.3) | 6 (54.6) | 11 (24.4) | ||
| Constipation | 0.931 | > 0.99 | ||||
| Yes | 61 (50.8) | 33 (51.6) | 6 (54.6) | 22 (48.9) | ||
| No | 59 (49.2) | 31 (48.4) | 5 (45.5) | 23 (51.1) | ||
| Vomiting | 0.807 | > 0.99 | ||||
| Yes | 43 (35.8) | 24 (37.5) | 3 (27.3) | 16 (35.6) | ||
| No | 77 (64.2) | 40 (62.5) | 8 (72.7) | 29 (64.4) | ||
| Weight loss | 0.480 | > 0.99 | ||||
| Yes | 10 (8.3) | 5 (7.8) | 3 (27.3) | 2 (4.4) | ||
| No | 110 (91.7) | 59 (92.2) | 8 (72.7) | 43 (95.6) | ||
| PPI | 0.090 | 0.807 | ||||
| Yes | 53 (44.2) | 33 (51.5) | 2 (18.2) | 18 (40.0) | ||
| No | 67 (55.8) | 31 (48.4) | 9 (81.8) | 27 (60.0) | ||
| Diabetes | 0.649 | 0.807 | ||||
| Yes | 20 (16.7) | 10 (15.6) | 1 (9.1) | 9 (20.0) | ||
| No | 100 (83.3) | 54 (84.4) | 10 (90.9) | 36 (80.0) | ||
| Prior GI surgery | 0.070 | 0.807 | ||||
| Yes | 31 (25.8) | 22 (34.4) | 2 (18.2) | 7 (15.6) | ||
| No | 89 (74.2) | 42 (65.6) | 9 (81.8) | 38 (84.4) | ||
| Age (yr) | 49.5 (34.0-63.0) | 46.5 (30.5-59.5) | 42.0 (41.0-65.0) | 52.0 (36.0-65.0) | 0.223 | |
| BMI (kg/m2) | 26.4 (21.0-31.1) | 26.4 (20.8-30.8) | 24.7 (18.7-37.1) | 26.6 (21.8-31.2) | 0.977 | |
a
We included 1 patient with maltase, sucrase, and palatinase deficiency in this group.
PPI, proton pump inhibitor; GI, gastrointestinal; BMI, body mass index.
Data are presented as number (%) or median (interquartile range).