Table 2.
Baseline Symptom Severity of Patients With Normal Enzymes vs Single Disaccharidase Deficiency vs Pan-disaccharidase Deficiency Patients
| Symptoms | Total (N = 120 [100.0%]) | Normal (n = 64 [53.3%]) | Pan-disaccharidase (n = 11 [9.2%]) | Single deficiency (n = 45 [37.5%])a | Raw P-value | Bonferroni adjustment |
|---|---|---|---|---|---|---|
| Pain | 6.1 (3.1) | 6.5 (2.7) | 4.7 (4.0) | 5.8 (3.4) | 0.207 | > 0.99 |
| Cramping | 4.7 (3.4) | 5.2 (3.3) | 4.3 (3.8) | 4.0 (3.4) | 0.251 | > 0.99 |
| Bloating | 6.3 (3.2) | 6.5 (2.9) | 6.3 (3.7) | 6.1 (3.5) | 0.851 | > 0.99 |
| Fullness | 6.1 (3.3) | 6.3 (3.2) | 5.9 (3.3) | 5.9 (3.6) | 0.865 | > 0.99 |
| Nausea | 4.6 (3.2) | 5.3 (3.2) | 2.4 (2.5) | 4.1 (3.2) | 0.023 | 0.253 |
| Belching | 4.1 (3.2) | 4.5 (3.3) | 3.9 (2.8) | 3.6 (3.2) | 0.432 | > 0.99 |
| Indigestion | 4.8 (3.5) | 5.2 (3.3) | 2.1 (3.2) | 4.8 (3.7) | 0.069 | 0.759 |
| Diarrhea | 3.9 (3.4) | 4.3 (3.4) | 3.1 (3.7) | 3.5 (3.5) | 0.469 | > 0.99 |
| Gas | 5.6 (3.0) | 5.9 (2.7) | 5.0 (3.3) | 5.2 (3.3) | 0.522 | > 0.99 |
| Constipation | 4.8 (3.6) | 5.3 (3.5) | 4.3 (4.4) | 4.1 (3.7) | 0.329 | > 0.99 |
| Vomiting | 2.0 (2.9) | 2.8 (3.2) | 0.3 (1.0) | 1.2 (2.2) | 0.010 | 0.110 |
a
We included 1 patient with maltase, sucrase, and palatinase deficiency in this group.
Data are presented as mean (SD).