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. 2020 May 9;9(3):202–211. doi: 10.1093/toxres/tfaa021

Figure 2.

Figure 2

Effect of CBD on Sigma1R in the VTA, NAc, HPC, and PFC of METH-induced CPP rats. Rats were pretreated with CBD (10, 20, 40, 80 mg/kg, IP) for 1 h before the administration of METH (2 mg/kg, IP). Sigma1R expression was detected via western blot analysis in the VTA (a), NAc (b), HPC (c), and PFC (d). Data were expressed as Sigma1R/β-actin and presented as mean ± SD from three independent experiments. (**P < 0.01, ***P < 0.001 vs. control; ##P < 0.01, ###P < 0.001 vs. METH group, N = 3 independent biological replicates per group). Representative images are shown.