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A sidechain-sidechain hydrogen bond is disrupted by a GAAGAA variant. In the wildtype GAAGAA protein, the NH1 atom of the Arg464 sidechain forms a hydrogen bond with the OD2 atom of Asp501. The NP_000143.2:p.Arg464Ser variant results in the loss of the hydrogen bonding partner for Asp502 sidechain.
