Figure 2. The Syn-Notch-mediated patterning system of Toda and colleagues [20].

(a) depicts the gene circuit in one cell (the outer oval represents the plasma membrane), and (b) depicts emergent multicellular behaviour. Cells adopt one of two fates according to the relative level of CD19-triggered SynNotch signal. This level depends weakly on noise and strongly on the state of their immediate neighbours. Having chosen a fate, the cells sort by Cdh1-mediated phase separation into two layers.