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. 2020 Jun 3;48(3):823–836. doi: 10.1042/BST20190363

Figure 2. Mechanism of eukaryotic DNA replication termination.

Figure 2.

Convergence of replication forks during termination is facilitated by Pif1 family helicases, likely due to their ability to unwind DNA in the opposite direction of CMG movement. CMGs continue to translocate on the leading strand templates and pass one another while leading strands continue to be extended. CMGs encounter the last Okazaki fragments on lagging strands and switch to encircle dsDNA. The last Okazaki fragments are processed by an unknown mechanism. CMGs are disassembled only after DNA has been fully ligated.