Table 4.
Suggestion no. | Action | Conditions |
---|---|---|
1 | Omit radiotherapy | Age ≥ 65 years (younger with comorbidities) + invasive breast cancer < 3 cm with clear margins + grade 1/2 + ER-positive and HER2-negative + node-negative + planned for endocrine therapy |
2 | Deliver radiotherapy in 5 fractions. 26 Gy in 5 daily fractions over 1 week or 28–30 Gy in once weekly fractions over 5 weeks [33] | For all patients requiring radiotherapy to the whole or partial breast or chest wall |
3 | Omit boost radiotherapy to reduce fractions or hypofractionation | Except in patients < 40 years age and those with a high risk of local recurrence |
4 | Omit nodal radiotherapy | Postmenopausal women with T1, grade 1–2, ER-positive, HER2-negative tumour with 1–2 macro metastases requiring whole breast radiotherapy following BCS and sentinel node biopsy [34] |