Fig. 5.

Meloxicam alters baseline haptoglobin associations with progressive metabolism of oxylipids. Linoleic acid-derived oxylipids in plasma for control ewes and ewes treated with 90 mg meloxicam on d 1 and 4 after lambing (mean ± SEM; μmol/L), expressed as ratios of select upstream:downstream metabolites. Shaded areas represent 95% confidence intervals and treatment (trt) is equal to 0 for MEL in the following eqs. a The 9-HODE/9-oxoODE ratio tended to have a treatment × covariate interaction (P = 0.06). Ewes with relatively greater proportion of 9-HODE at d 1 had a greater ratio on d 4 for MEL, but control ewes with a greater ratio at d 1 had a relatively lesser ratio at d 4. D 4 9-HODE/9-oxoODE = − 10.34 + 7.96 × covariate – 1.12 × covariate² + 24.76[control] – 14.24 × covariate[control] + 2.00 × covariate²[control]. b The 13-HODE/13-oxoODE ratio tended to have treatment × covariate interaction (P = 0.06). Progressive metabolism from 13-HODE to 13-oxoODE was greater for MEL with greater initial ratio, but there was less progressive metabolism for CON ewes with greater initial ratios. D 4 13-Hode/13-oxoODE = 60.78–0.25 × covariate + 0.00065 × covariate²–66.97[control] + 1.77 × covariate[control] – 0.0054 × covariate²[control]