Table 8.

Plasma concentrations of oxidized linoleic acid metabolites derived from multiple sources and ratios of select upstream:downstream metabolites in control ewes and ewes treated with 90 mg meloxicam on d 1 and 4 after lambing (mean ± SEM; μmol/L)

				P-values1
Oxylipid or Ratio2	CON	MEL	SEM	Trt	Cov	Cov × trt	Lambs	Hpcov × trt
9-HODE	52.5	44.9	4.2	NS	0.01	0.07	0.03	<  0.01
9-oxoODE	13.99	12.37	1.24	NS	NS	NS	0.01	0.02
13-HODE	133.0	124.8	8.45	NS	NS	<  0.01	NS	NS
13-oxoODE	1.90	2.55	0.31	NS	NS	NS	NS	NS
9-HODE:9-oxoODE3	3.35	3.59	0.17	NS	NS	0.06	0.06	<  0.10
13-HODE:13-oxoODE4	62.3	51.1	5.4	NS	NS	0.04	NS	NS
9,10-EpOME:9,10-DiHOME	0.37	0.46	0.03	0.06	–	–	–	–

¹NS = P > 0.10

²HODE Hydroxyoctadecadienoic acid, oxoODE Oxooctadecadienoic acid, EpOME Epoxyoctadecenoic acid, DiHOME Dihydroxyoctadecenoic acid

³Cov × cov × trt: P = 0.06

⁴Cov × cov: P = 0.09; Cov × cov × trt: P = 0.04