Fig. 6.

The possible mechanisms of γδ cell promotion of liver fibrosis. a, b CD11b⁺Gr-1⁺ cells in WT mouse liver expressed IL-17RA at 4 (a) and 6 (b) weeks post-infection. c, d CD11b⁺Gr-1⁺ cells in WT mouse spleen expressed IL-17RA at 4 (c) and 6 (d) weeks post-infection. e CD11b⁺Gr-1⁺ cells in WT mouse liver expressed TGF-β at 6 weeks post-infection. f CD11b⁺Gr-1⁺ cells in KO mouse liver expressed TGF-β at 6 weeks post-infection. g Statistical analysis of the percentage of TGF-β in CD11b⁺Gr-1⁺ cells from WT and KO mouse liver. Liver leukocytes were stimulated with PMA + ionomycin for 4 h; intracellular TGF-β staining was performed, and representative dot plots are shown. Student’s t-test was applied to two groups at six weeks, n = 5 per group, **P < 0.01