Fig. 1.

Fyn Kinase Inhibition Prevents Memory Deficits in P301S Tau Transgenic Mice. (a) Timeline of PS19 mouse treatment. (b) Morris water maze probe trial for 8-month-old PS19 or WT mice after 6 months of AZD0530 or Vehicle treatment. Twenty four hours after the reverse learning trials in the Morris water maze, the submerged platform was removed and the fraction of 60 s spent in the target quadrant where the hidden platform had been located previously was recorded. n = 11–15 /group, each dot is one mouse. Data are mean ± SEM. Dashed line indicates random chance performance. Two-way ANOVA reveal an interaction between genotype and treatment (p = 0.014). *p < 0.05; Sidak’s post-hoc multiple comparisons test. (c) Passive avoidance test for 8-month-old PS19 and WT mice after 6 months of treatment with AZD0530 or Vehicle. Latency was measured as the time for the mouse to cross to the opaque box. n = 16–18 /group. Wilcoxon match-pairs signed test; (WT, Vehicle: p = 0.0007; WT, AZD0530: p < 0.0001; PS19, AZD0530: p = 0.1167; PS19, AZD0530: p = 0.0126)