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. 2020 Jul 1;8:96. doi: 10.1186/s40478-020-00976-9

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Reduced phospho-Tau Accumulation in Transgenic Mice Treated with AZD0530. (a) Representative images of AT8 immunoreactivity in the dentate gyrus (DG) of the hippocampus in 9-month-old PS19 mice after 7 months of treatment with AZD0530 or Vehicle. Scale bar, 20 μm. (b) Quantification of AT8-positive area (%) in the dentate gyrus of the hippocampus in 9-month-old PS19 and WT mice after 7 months of treatment. Data are mean ± SEM. n = 7–10 /group, each dot is the average of three sections from one mouse. Two-way ANOVA revealed an interaction between genotype and treatment (p = 0.0487). *p < 0.05; Sidak’s post hoc multiple comparisons test. (c) Representative images of immunofluorescent staining for AT8 in the CA1 of the hippocampus in 9-month-old PS19 mice after 7 months of treatment. Scale bar, 20 μm. (d) Quantification of AT8-positive area in the CA1 of the hippocampus in 9-month-old PS19 and WT mice after 7 months of treatment. Data are mean ± SEM. n = 7–10 /group, each dot is the average of three sections from one mouse. Two-way ANOVA revealed an interaction between genotype and treatment (p = 0.03). *p < 0.05; Sidak’s post hoc multiple comparisons test. (e) Representative images of immunofluorescent staining for PHF1 in the CA1 of the hippocampus in 9-month-old PS19 mice after 7 months of treatment. Scale bar, 20 μm. (f) Quantification of PHF1-positive area in the CA1 of the hippocampus in 9-month-old PS19 and WT mice after 7 months of treatment. Data are mean ± SEM. n = 6–10 /group, each dot is the average of three sections from one mouse. Two-way ANOVA revealed an interaction between genotype and treatment (p = 0.0341). **p < 0.01; Sidak’s post hoc multiple comparisons test. g) Representative images of immunofluorescent staining for HT7 in the CA1 of the hippocampus in 9-month-old PS19 mice after 7 months of treatment. Scale bar, 20 μm. (h) Quantification of HT7-positive area in the CA1 of the hippocampus in 9-month-old PS19 and WT mice after 7 months of treatment. Data are mean ± SEM. n = 7–9 /group, each dot is the average of three sections from one mouse. Two-way ANOVA revealed a main effect of genotype (p < 0.0001) but no interaction between genotype and treatment (p = 0.5181); Sidak’s post hoc multiple comparisons test