Table 2.
Pre- to post-treatment changes in functional connectivity from whole-brain PPI analysis using left and right amygdala seed regions (contrast: ‘Post [Affect Label – Gender Label] – Pre [Affect Label – Gender Label]’) correlated with change in symptom composite scores from 6 to 12-month follow-up, controlling for pre-treatment symptom composite scores. Peak Montreal Neurological Institute (MNI) coordinates and respective Broadmann’s Areas (BA) are reported for each cluster. All p < 0.05, corrected (see Methods).
Amygdala seed (L/R) | Anatomical Region | BA | MNI Coordinates | Cluster size (voxels) | Peak t value |
||
---|---|---|---|---|---|---|---|
x | y | z | |||||
Changes in functional connectivity (Post-Pre) correlation with 12 mo. Symptom Composite | |||||||
Affect Label > Gender Label | |||||||
L | dmPFC / R dACC | 9/10 | 0 | 53 | 25 | 152 | 4.288 |
L | mid/posterior cingulate, L calcarine, L/R precuneus | 23/29/31 | 3 | −40 | 19 | 295 | 5.170 |
L | L/R precuneus | 7 | −3 | −52 | 52 | 129 | 5.039 |
L | L cerebellum, L lingual gyrus, L fusiform | 37 | −33 | −49 | −26 | 150 | −4.473 |
L | L post-central gyrus, L pre-central gyrus | 2/3/4 | −45 | −10 | 46 | 217 | −4.348 |