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. Author manuscript; available in PMC: 2020 Aug 7.
Published in final edited form as: Mod Pathol. 2020 Feb 7;33(7):1341–1349. doi: 10.1038/s41379-020-0495-2

Figure 2. NTRK3 mRNA up-regulation in BCOR family tumors using whole transcriptome sequencing (A) and targeted RNA sequencing (B).

Figure 2.

Up-regulated NTRK3 expression was observed in round cell sarcomas with BCOR ITD, YWHAE rearrangements, BCOR-CCNB3, KMT2D-BCOR, and BCOR-CHD9 fusions, compared to other sarcomas on each platform (expression levels in RPKM). The NTRK3 levels observed in targeted RNA sequencing were higher than an infantile fibrosarcoma with EML4-NTRK3 fusion reference (B). An ossifying fibromyxoid tumor with ZC3H7B-BCOR fusion (A) and a synovial sarcoma (B) also had relatively increased NTRK3 expressions. No significant increase of NTRK3 expression level was observed in the single case of round cell sarcoma with BCOR-MAML3 fusion, an Ewing sarcoma with EWSR1-ERG fusion, 9 CIC-DUX4 sarcomas (A), and solitary fibrous tumors (B).