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. Author manuscript; available in PMC: 2020 Aug 7.
Published in final edited form as: Mod Pathol. 2020 Feb 7;33(7):1341–1349. doi: 10.1038/s41379-020-0495-2

Figure 4. Alternative BCOR fusions overexpressing pan-Trk.

Figure 4.

Kidney tumor with the novel BCOR-CHD9 fusion in an adult female patient (A-E) showing primitive round to short spindle cell morphology (A) and strong pan-Trk staining (C), while being negative for BCOR (B) and NTRK1 (D). Loss of H3K27me3 expression was identified (E). Two cases with KMT2D-BCOR fusion showed a monotonous round to spindle morphology (F-J, pelvic tumor of a 10-year-old female; K-O, scapular tumor of a 38-year-old male patient), positive immunostaining for BCOR (G, L), pan-Trk (H, M), and TLE1 (J, N). NTRK1 staining was negative (I). Loss of H3K27me3 expression was also identified (O).