Figure 2.

Correlation of biomarker levels with end row loop (ERL) scores. A panel of biomarkers for endothelial dysfunction and inflammation was measured by multiplex assay in the serum of 30 treatment‐naive juvenile dermatomyositis (DM) patients (discovery cohort). ERL scores (a count of ERLs/mm in the fingers, as a measure of the severity of vasculopathy) were assessed by nailfold capillaroscopy. A, Spearman's rank correlations (r_s) were determined to assess the correlation between serum biomarker levels and ERL scores in 29 juvenile DM patients. B, Serum levels of endoglin and soluble intercellular adhesion molecule 1 (sICAM‐1) were assessed in juvenile DM patients stratified according to low ERL scores (defined as <4) and high ERL scores (defined as ≥4). Symbols represent individual patients; horizontal lines show the median. Values above the graphs are P values, determined by Mann‐Whitney U test. TSP‐1 = thrombospondin‐1; VEGF = vascular endothelial growth factor.