Fig. 4.

Therapeutic applications of LNPs enabling genetic drug delivery. LNPs can deliver siRNA, mRNA, DNA, or gene editing complexes, providing opportunities to treat hepatic diseases by silencing pathogenic genes, expressing therapeutic proteins, or correcting genetic defects. Following LNP internalization, nucleic acid therapeutics are released into the cytoplasm. DNA vectors require nuclear translocation to be active. Adapted with permission from Buck et al. [169]. Copyright 2019 American Chemical Society.