Table A3.
Geometric mean antibody concentration (GMC) for HPV-16 and HPV-18 antibodies in subjects seronegative at baseline by ELISA (TVC).
| anti-HPV-16 antibody (IU/mL) | AS04-HPV-16/18 WLWH |
4vHPV WLWH |
AS04-HPV-16/18 without HIV |
4vHPV without HIV |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GMC | 95%CI | GMC | 95%CI | GMC | 95%CI | GMC | 95%CI | |||||
| VISIT1 (D0) | 1.6 | 1.6 | 1.6 | 1.6 | 1.6 | 1.6 | 1.6 | 1.6 | 1.6 | 1.6 | 1.6 | 1.6 |
| VISIT2 (W6) | 30.3 | 22.6 | 40.5 | 22.9 | 17.2 | 30.6 | 53.2 | 44.2 | 63.9 | 35.2 | 30.0 | 41.2 |
| VISIT3 (W10) | 343.5 | 275.6 | 428.2 | 194.9 | 151.9 | 250.2 | 578.0 | 472.5 | 707.0 | 357.1 | 293.7 | 434.3 |
| VISIT5 (M7) | 752.3 | 566.2 | 999.5 | 354.9 | 269.5 | 467.4 | 2123.6 | 1621.0 | 2782.1 | 777.9 | 611.2 | 990.1 |
| VISIT6 (M12) | 189.1 | 140.2 | 255.1 | 92.2 | 68.1 | 124.8 | 642.7 | 504.6 | 818.8 | 274.9 | 226.2 | 334.1 |
| VISIT7 (M18) | 119.1 | 89.9 | 157.7 | 43.5 | 32.1 | 58.9 | 348.3 | 284.6 | 426.4 | 118.6 | 98.8 | 142.4 |
| VISIT8 (M24) | 96.8 | 71.7 | 130.7 | 33.7 | 25.0 | 45.5 | 281.8 | 226.8 | 350.2 | 91.5 | 76.2 | 109.9 |
| anti-HPV-18 antibody (IU/mL) | AS04-HPV-16/18 WLWH |
4vHPV WLWH |
AS04-HPV-16/18 without HIV |
4vHPV without HIV |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GMC | 95%CI | GMC | 95%CI | GMC | 95%CI | GMC | 95%CI | |||||
| VISIT1 (D0) | 1.6 | 1.6 | 1.6 | 1.6 | 1.6 | 1.6 | 1.6 | 1.6 | 1.6 | 1.6 | 1.6 | 1.6 |
| VISIT2 (W6) | 19.8 | 15.2 | 25.8 | 7.0 | 5.3 | 9.3 | 45.2 | 37.2 | 54.9 | 9.8 | 8.1 | 11.7 |
| VISIT3 (W10) | 280.6 | 225.7 | 348.8 | 40.5 | 30.9 | 53.2 | 457.4 | 373.4 | 560.3 | 85.1 | 68.7 | 105.3 |
| VISIT5 (M7) | 486.6 | 381.5 | 620.7 | 82.8 | 60.9 | 112.6 | 1010.8 | 777.7 | 1313.7 | 217.4 | 170.2 | 277.7 |
| VISIT6 (M12) | 121.2 | 91.7 | 160.2 | 18.0 | 13.1 | 24.6 | 278.7 | 219.2 | 354.2 | 60.9 | 48.3 | 76.9 |
| VISIT7 (M18) | 69.9 | 52.9 | 92.5 | 9.1 | 6.8 | 12.3 | 156.3 | 126.3 | 193.3 | 25.8 | 20.8 | 32.0 |
| VISIT8 (M24) | 53.4 | 39.2 | 72.8 | 8.0 | 6.0 | 10.6 | 132.8 | 106.9 | 164.9 | 19.7 | 15.9 | 24.5 |
ATP: according to protocol;D: Day; CI: confidence interval; GMC: geometric mean concentration; HIV: human immunodeficiency virus; HPV: human papillomavirus; IU: International unit; M: Month; W: Week; WLWH: women living with HIV.