Table 2.
The risk of developing a central sensitivity syndrome in those exposed and unexposed to childhood maltreatment.
| Childhood maltreatment | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fibromyalgia |
Chronic fatigue syndrome |
Temporomandibular joint disorder |
Chronic lower back pain |
Chronic headache |
Myofascial pain syndrome |
|||||||
| Exposed | Unexposed | Exposed | Unexposed | Exposed | Unexposed | Exposed | Unexposed | Exposed | Unexposed | Exposed | Unexposed | |
| Number of Patients | 80476 | 161150 | 80486 | 160972 | 80037 | 159956 | 80378 | 161025 | 80633 | 161292 | 80650 | 161307 |
| Numbers of Outcomes | 300 | 209 | 88 | 97 | 445 | 787 | 361 | 261 | 21 | 31 | 8 | 16 |
| Person-years | 292791 | 553912 | 293326 | 553628 | 290371 | 547522 | 292265 | 553294 | 294175 | 554996 | 294234 | 555031 |
| Incidence Rate (per 100000 person years) | 102.46 | 37.73 | 30.00 | 17.52 | 153.25 | 143.74 | 123.52 | 47.17 | 7.14 | 5.59 | 2.72 | 2.88 |
| Incidence Rate Ratio (95% Confidence intervals)* | 2.72 (2.28-3.24) | 1.71 (1.28-2.29) | 1.07 (0.95-1.20) | 2.62 (2.23-3.07) | 1.28 (0.73-2.22) | 0.94 (0.40-2.20) | ||||||
| P value | <0.001 | <0.001 | 0.280 | <0.001 | 0.385 | 0.893 | ||||||
| Adjusted Incidence Rate Ratio (95% Confidence intervals)⁎⁎ | 2.06 (1.71 -2.48) | 1.47 (1.08-2.00) | 1.00 (0.88-1.13) | 1.99 (1.68-2.35) | 1.04 (0.59-1.86) | 0.88 (0.36-2.14) | ||||||
| P value | <0.001 | 0.015 | 0.953 | <0.001 | 0.888 | 0.775 | ||||||
| Restless leg syndrome |
Interstitial cystitis |
Vulvodynia |
Chronic prostatitis |
Irritable bowel syndrome |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Exposed | Unexposed | Exposed | Unexposed | Exposed | Unexposed | Exposed | Unexposed | Exposed | Unexposed | |
| Number of Patients | 80600 | 161216 | 80645 | 161295 | 47034 | 94072 | 33612 | 67214 | 77889 | 157095 |
| Numbers of Outcomes | 149 | 122 | 10 | 15 | 14 | 33 | <5 | 9 | 1750 | 2643 |
| Person-years | 293552 | 554412 | 294199 | 555030 | 171833 | 303854 | 122371 | 251109 | 277110 | 530415 |
| Incidence Rate (per 100000 person years) | 50.76 | 22.01 | 0.34 | 0.27 | 8.15 | 10.86 | 1.63 | 3.58 | 631.52 | 498.29 |
| Incidence Rate Ratio (95% Confidence intervals)* | 2.30 (1.82-2.93) | 1.26 (0.57-2.80) | 0.75 (0.40-1.40) | 0.46 (0.10-2.11) | 1.27 (1.19-1.35) | |||||
| P value | <0.001 | 0.574 | 0.368 | 0.315 | <0.001 | |||||
| Adjusted Incidence Rate Ratio (95% Confidence intervals)⁎⁎ | 1.82 (1.41-2.35) | 1.19 (0.51-2.74) | 0.65 (0.34-1.26) | 0.34 (0.07-1.77) | 1.15 (1.08-1.22) | |||||
| P value | <0.001 | 0.691 | 0.203 | 0.201 | <0.001 | |||||
| All somatic syndromes |
All visceral syndromes |
|||
|---|---|---|---|---|
| Exposed | Unexposed | Exposed | Unexposed | |
| Number of Patients | 79364 | 159074 | 77874 | 157051 |
| Numbers of Outcomes | 1250 | 1432 | 1768 | 2689 |
| Person-years | 285536 | 542495 | 277014 | 530210 |
| Incidence Rate (per 100000 person years) | 437.77 | 263.97 | 638.23 | 507.16 |
| Incidence Rate Ratio (95% Confidence intervals)* | 1.66 (1.54-1.79) | 1.26 (1.19-1.34) | ||
| P value | <0.001 | <0.001 | ||
| Adjusted Incidence Rate Ratio (95% Confidence intervals)⁎⁎ | 1.41 (1.31-1.53) | 1.14 (1.07-1.22) | ||
| P value | <0.001 | <0.001 | ||
⁎
Unadjusted incidence rate ratio
⁎⁎
Adjusted Incidence rate ratio: adjusted for age, sex, depression, anxiety, serious mental ill health and Townsend deprivation score at baseline