Table 2. Associations between KIT Mutations and Various Clinicopathological Features/Races of Melanomas.
Clinicopathologic characteristics | OR | 95% CI | p value | Association with KIT mutation |
---|---|---|---|---|
Age (≥60 yr) | ||||
Asian | 1.349 | 1.056–1.723 | 0.017 | Positive |
White | 0.795 | 0.337–1.879 | 0.602 | None |
Overall | 1.296 | 1.025–1.641 | 0.031 | Positive |
Sex | ||||
Asian | 1.134 | 0.910–1.412 | 0.264 | None |
White | 0.860 | 0.426–1.735 | 0.674 | None |
Overall | 1.106 | 0.897–1.364 | 0.347 | None |
Mucosal melanoma | ||||
Asian | 1.080 | 0.842–1.386 | 0.545 | None |
White | 3.003 | 1.895–4.758 | <0.001 | Positive |
Overall | 1.363 | 1.094–1.697 | 0.006 | Positive |
Acral melanoma | ||||
Asian | 1.361 | 1.087–1.702 | 0.007 | Positive |
White | 1.435 | 0.901–2.286 | 0.128 | None |
Overall | 1.374 | 1.123–1.682 | 0.002 | Positive |
Cutaneous melanoma with NCSD | ||||
Asian | 0.613 | 0.424–0.886 | 0.009 | Negative |
White | 0.094 | 0.018–0.500 | 0.006 | Negative |
Overall | 0.562 | 0.392–0.805 | 0.002 | Negative |
Cutaneous melanoma with CSD | ||||
Asian | 1.643 | 0.962–2.806 | 0.069 | None |
White | 7.791 | 1.370–44.291 | 0.021 | Positive |
Overall | 1.880 | 1.127–3.136 | 0.016 | Positive |
Melanoma on the extremities | 0.294 | 0.105–0.820 | 0.019 | Negative |
Breslow thickness | ||||
>1 mm | 0.910 | 0.586–1.413 | 0.674 | None |
>4 mm | 1.177 | 0.928–1.492 | 0.179 | None |
Ulceration | 0.968 | 0.772–1.215 | 0.781 | None |
CSD, chronically sun-damaged; NCSD, non-CSD; OR, odds ratio; CI, confidence interval.