Table 4.

Findings of disease progression involving peritoneal metastasis

Progression of peritoneal metastasis

Aggravation of peritoneal mass, intestinal wall thickening, ascites, and intestinal stenosis

Aggravation of intestinal obstruction or stenosis symptoms, such as decreased food intake, abdominal pain, nausea and vomiting not attributable to chemotherapy-related adverse events

Aggravation of the feeling of abdominal fullness

Deterioration of renal function (emergence of hydronephrosis due to aggravation of peritoneal dissemination)

Deterioration of general condition such as a decrease in performance status determined to be caused by the original disease

An increase in the number of times that ascites drainage is required

Disease progression difficult to determine from imaging test results

Exacerbation of cancer pain

Deterioration of general condition such as a decrease in performance status determined to be caused by the original disease

The emergence and worsening of disseminated intravascular coagulation

An increase in tumor markers