Table 3.
Geometric mean (95% confidence interval) and area under the curve of samples from 2 to 4 h(AUC2–4) and metabolic clearance (Clmet) after midazolam 30 µg under different co-medications
| Midazolam dose | Yohimbine dose | Paroxetine dose | AUC2–4 (pg/mL*h) | Clmet (mL/min) |
|---|---|---|---|---|
| 30 µg | – | 371 (227–606) | 545 (414–717) | |
| 30 µg | 50 µg | 259 (147–456) | 584 (459–744) | |
| 30 µg | 5 mg | 351 (217–568) | 575 (457–722) | |
| 30 µg | 20 mg | 286 (176–464) | 613 (476–790) | |
| 30 µg | 50 µg | 20 mg | 340 (200–577) | 607 (474–779) |
| 30 µg | 5 mg | 20 mg | 317 (180–559) | 652 (516–824) |