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. 2020 Jul 1;22(4):89. doi: 10.1208/s12248-020-00473-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Mass spectra of Sample #13 (ER drug product) spiked with 20 ng/mL of NDMA which also contained DMF (top) and EICs (bottom) demonstrating the overestimation (integrated area of 2,944,523 with ± 15 ppm mass tolerance in the left panel (blue bar), while there is an integrated area of 9,013,116 with ± 30 ppm mass tolerance in the right panel (dotted bar)) of NDMA as the results of DMF interference from C₃H₇¹⁵NO