. 2020 Jul 1;22(4):89. doi: 10.1208/s12248-020-00473-w

Table 2.

Comparison of mass spectrometry (MS) conditions used in this study (FDA) and the private laboratory method description

MS Conditions	Private laboratory	FDA
Instrument	QToF	Orbitrap
Ionization mode	APCI, positive	APCI, positive
Data acquisition	MRMHR	Targeted MS2
MS scan	50–450 m/z	40–90 m/z
Mass resolution	> 25,000^a	45,000^b
Transition(s)	75.0553 → 75.0553	75.0553 → 75.0553
	83.0997 → 83.0997	83.0997 → 83.0997

^abThe maximum resolution is specified as ≥ 42,000 (FWHM) at m/z 956 for this instrument; The maximum resolution is specified as 480,000 at m/z 200 for this instrument