Table 1.
CBS deficiency-responsive proteins unique to, or shared between, mice and humans.
| Unique to mice (n = 96)a | Unique to humans (n = 20)a | Proteins affected in mice and humans (n = 21)b | ||
|---|---|---|---|---|
| ↑Actb | ↓DnaH8 | ↑Mup20 | ↑APOC1 | ↓AFM↓ |
| ↑ApoA4 | ↑FetuB | ↑Qsox1 | ↓APOC3 | |
| ↑ApoB | ↑Gpld1 | ↑Pi16 | ↑GSN | |
| ↑ApoD | ↑H2Q10 | ↑Pltp | ||
| ↑ApoE | ↓Hgfac | ↓Pon1 | ||
| ↑Azgp1 | ↓Igfals | ↑Psap | ↑APOM↓ | |
| ↓Ces1c | ↑Lcat | ↑Sepp1 | ||
| Ces2e | ↓Lifr | ↑Serpina7 | ||
| ↓Cd5l | ↑Lrg1 | ↑Sod3 | ↑GC↓ | |
| ↑CtsB | ↑Lum | ↑Thbs1 | ↑GPX3↑ | |
| ↑Csf1r | ↓Mgam | ↑Vtn | ||
| Acute phase response (n = 12): ↑Agt, ↑Apcs, ↑ApoA2, ↑Ambp, ↑Cp, ↑Crp, ↓Fn1, ↑Hp, ↑Itih3, ↑Orm1, ↑Serpina3n, ↑Tf |
Acute phase response (n = 2): ↑SAA1, ↓TTR |
Acute phase response (n = 3): ↑APOA1↓, ↑HPX↓, ↑ORM2↓ |
||
|
Blood coagulation (n = 4): ↑F10, ↑Serpina1b, ↑Serpina10, ↑Pros1 |
Blood coagulation (n = 5): ↓A1BG, ↓F13B, ↑FBLN1, ↓KNG1, ↑SERPINA1 |
Blood coagulation (n = 6): ↑AHSG↓, ↑APOH↓, ↑ITIH2↓, ↑SERPIND1↓, ↑SERPINF2↓, ↑SERPINC1↓ | ||
| Complement/coagulation (n = 16): ↑C1qa, ↑C1qb, ↑C1qc, ↑C4b, ↓C4bp, ↑C6, ↑Cfb, ↑Cfd, ↓Cfh, ↓Cpn2, ↑Fcn-1, ↓Gm4788, ↓Mbl1; ↑Mbl2; ↑Serping1, ↓SERPINA1d |
Complement/coagulation (n = 3): ↑C9, ↓F2, ↓FCN3 |
Complement/coagulation (n = 6): ↑C1R(C1ra)↓, ↑C1S(C1rs)↓, ↑CF1↓ ↑CPB2↑, ↓CPN1↓, ↓KLKB1↓, |
||
| Immune response (n = 31): ↓Igh (n = 18), ↓Igk (n = 11), Igl (n = 2) | Immune response (n = 7): ↑HEL-213, ↓IGH@, ↑IGHD, ↑IGHV3-7, IGHV3-72, ↑IGK@, ↓IGKV2D-24 | Immune response (n = 2): ↑CLU↓, ↓IGJ↑ | ||
Proteins highlighted in bold are associated with stroke subtypes in humans (Sikora et al.12).
aUp and down arrows indicate the direction of change in protein levels.
bArrows left and right to the protein acronym refer to the change in protein levels in mice and humans, respectively.