Table 2.
Cardinal and reactional candidate genes obtained from the whole-transcriptome profiling using hypothesis free and pathway-guided algorithms.
| Hypothesis-free algorithm | |||
|---|---|---|---|
| Gene | Averaged FC (NR/ RESP) | p-corr. value | Functional relevance |
| TBC1D9 | −3.59 | 0.043 | Linked to ADHD46. |
| UNC13C | −4.07 | 0.049 | Might be involved in PTSD75. |
| RAMP1 | −4.63 | 0.043 | Activity modifying protein for CGRP-receptor76. CGRP has been linked in depression patients CSF and plasma77. |
| FYB | −3.49 | 0.043 | Adapter for FYN, which in turn was associated with long term potentiation78. |
| CTNNA2 | −3.55 | 0.043 | Found related to bipolar disorder79. |
| NFIB | +3.75 | 0.049 | Found involved in depression and antidepressant effects in animal models41. |
| GAD1 | +3.10 | 0.020 | Linked to depression and antidepressant response29,30. |
| PITX1 | +4.12 | 0.049 | SNPs were associated with autism80 |
| RBPMS | +6.47 | 0.047 | Loss of function leads to decreased arborization of axons81. |
| Pathway-guided algorithm | |||
|---|---|---|---|
| Gene | Averaged FC (NR/ RESP) | p-corr. value | Functional relevance |
| NRP1 | +2.75 | 0.046 | Upregulated in postmortem brains from depressed patients82. |
| FGF7 | −2.10 | 0.013 | Involved in inhibitory synapse formation83. |
| EPHB2 | +2.36 | 0.018 | linked to depression-like behaviors in animal models84. |
| ITGB6 | −2.40 | 4.66E−03 | Linked to antidepressant response in MARS cohort9. |
| AADAT | +2.60 | 9.44E−03 | Polymorphism was found to modulate SSRI response85. |
| GRIN2A | −2.69 | 3.05E−04 | Found to be hypermethylated in the hippocampus of MDD patients86. |
| NINL | −2.75 | 0.031 | Quantitative traits-associated susceptibility loci for brain development87. |
| GAD1 | +3.10 | 0.043 | Expression and variants were linked to depression and antidepressant response29,30. |
Fold-change differential expression in the response groups and functional relevance of each gene are shown.