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. 2020 Jul 1;10:10753. doi: 10.1038/s41598-020-67485-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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One hundred and fourteen EEG or VEEG recordings were obtained from 92 patients. EEG BA was significantly aggravated at 12 days (A,C,E,G). A total of 107 EEGs and CSF antibody titers were collected from 85 patients. 76 first EEGs ranging from 12 to 60 days (median 19.5 days) from 76 patients were analyzed. SDPS was observed in 15 anti-NMDAR encephalitis patients; moderate DPS in 32 patients; mild DPS in 25 patients, and normal in 4 patients (Table 1). (B vs D) BA during the peak stage in female patients with high CSF antibody titers was more severe than that in patients with low CSF antibody titers (Mann–Whitney U test, P = 0.000). (B vs F) BA with high CSF antibody titers at the peak stage was more severe in female patients than in male patients (Mann–Whitney U test, P = 0.000). (H) SDPS was not observed in male patients with low CSF antibody titers. Mild DPS mild diffuse polymorphic slowing, Moderate DPS moderate diffuse polymorphic slowing, SDPS severe diffuse polymorphic slowing. Purple bubble patients with EEGs and CSF antibody titers. Red bubble with EEGs and unclear CSF antibody titers: X-axis: time. Y-axis: number of patients.