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. 2020 Jul 1;11(7):498. doi: 10.1038/s41419-020-2705-8

Fig. 5. ETS1 is upregulated in mice and human with H.pylori infection and associate with the degree of gastric inflammation.

Fig. 5

a ETS1 mRNA expression in gastric mucosa of H. pylori-infected (H. pylori (+)) (n = 53) and uninfected donors (H. pylori (−)) (n = 20) were compared. b Dynamic changes of Ets1 mRNA expression in H. pylori 11637-infected and uninfected wild-type C57BL/6 mice (n = 5). c ETS1 protein expression in gastric mucosa of H. pylori (+) and H. pylori (−) was analyzed by immunohistochemistry staining. Scale bar: 100 μm. d Ets1 protein expression in gastric mucosa of H. pylori 11637-infected and uninfected mice at 12 week p.i. was analyzed by immunohistochemical staining. Scale bar: 100 μm. e, f ETS1/Ets1 protein in human gastric mucosa of H. pylori (+) and H. pylori (−) or in mice gastric mucosa of H. pylori 11637-infected and uninfected mice at 12 week p.i. was analyzed by western blot. g ETS1 mRNA expression in gastric mucosa of H. pylori (+) patients with mild (n = 25), moderate (n = 16), severe (n = 12) inflammation were compared. *P < 0.05, **P < 0.01.