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. 2020 Jul 1;10:10745. doi: 10.1038/s41598-020-67518-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Disorganization of GP chondrocytes during experimental knee osteoarthritis (OA). Destabilization of medial meniscus (DMM) was induced in 12 weeks old mice, that were sacrificed 8 weeks after surgery. Post-traumatic damage accounted for the articular cartilage (AC) lesions, regarding proteoglycan loss, cartilage fibrillation and vertical clefts observed in the AC. (a) Representative mice joint sections stained with Safranin-O Fast Green at × 5 and × 20 magnification from non-operated wild type (NO-WT) and DMM-WT mice (bars = 250 and 100 µm respectively). (b) Histopathological OARSI Score represented as the sum of tibia and femur scores. (c) Representative Haematoxilin-Eosin stained tibia growth plate (GP) sections at × 40 magnification from NO-WT and DMM-WT mice (bars = 50 µm). (d) Percentage of cells in columns and column index (CI) in the GP in NO-WT and DMM-WT mice. Data are shown as median ± interquartile range (IQR). (e) Association between the percentage of cells in columns and OARSI score, and between CI and OARSI score in WT mice. NO-WT, n = 10–16; DMM-WT, n = 11–12.