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. 2020 Jul 1;10:10733. doi: 10.1038/s41598-020-67645-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PPH-5 enables the formation of open and closed HSP-90 complexes. (A) Sedimentation velocity AUC analysis of *GRLBDm (grey), *GRLBDm ·HSP-90 (red), *GRLBDm·HSP-90/ATPγS (navy), *GRLBDm·HSP-90·PPH-5 (yellow), *GRLBDm·HSP-90/ATPγS·PPH-5 (green) complexes. (B) Influence of AHSA-1 (green), STI-1 (petrol) and FKB-6 (navy) cofactors on the formation of *GRLBDm·HSP-90 complexes analyzed by sedimentation velocity AUC. (C) The same experimental setup with AHSA-1 (green), STI-1 (petrol) and FKB-6 (navy) was performed in the presence of ATPγS to initiate the closing reaction of HSP-90.