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. 2020 Jul 1;10:10740. doi: 10.1038/s41598-020-67563-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of CIMVs-MSCs distribution in vivo (A–D) and ex vivo (E,F). Biodistribution of CIMVs-MSCs after i.v. injection (A), s.c. injection (B–D) and i.m. injection (B–D). (A) 1 h after i.v. injection; (B) 1 h after s.c. and i.m. injection; (C) 48 h after s.c. and i.m. injection; (D) 14 days after s.c. injection; and i.m. injection; (E) organs were collected one hour after i.v. injection of CIMVs-MSCs (experiment; left Petri dish) or PBS (control; right Petri dish); (F) organs were collected 48 h after i.v. injection of CIMVs-MSCs (experiment; left Petri dish) or PBS (control; right Petri dish). 1—s.c. injection 25 µg of CIMVs-MSCs; 2—s.c injection 50 µg of CIMVs-MSCs; 3—i.m. injection 50 µg of CIMVs-MSCs, 4—brain, 5—heart, 6—lung, 7—liver, 8—kidneys, 9—spleen. Images were captured using IVIS Imaging System.