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. 2020 Jun 25;14:186. doi: 10.3389/fncel.2020.00186

Figure 4.

Figure 4

Augmented HIF-1α/BDNF/ TrkB/CREB pathway protein expression after exercise. Compared to rested rats, levels of HIF-1α (A; 0.6 vs. 0.3 at 3 days, *p < 0.05; 0.8 vs. 0.6 at 14 days; 0.7 vs. 0.2 at 28 days, **p < 0.01), BDNF (B; 0.4 vs. 0.2 at 3 days; 1.5 vs. 0.5 at 14 days; 0.6 vs. 0.2 at 28 days), NGF (C; 1.1 vs. 0.7 at 3 days; 1.6 vs. 0.7 at 14 days, ***p < 0.001; 0.6 vs. 0.3 at 28 days, ***p < 0.001), TrkB (D; 1.0 vs. 0.6 at 3 days, *p < 0.05; 1.4 vs. 0.4 at 14 days, **p < 0.01; 0.3 vs. 0.2 at 28 days, *p < 0.05), and CREB (E; 1.4 vs. 5.5 at 3 days, ***p < 0.001; 0.4 vs. 0.2 at 14 days, **p < 0.01; 0.6 vs. 0.4 at 28 days, **p < 0.01) in mildly exercised rats were significantly increased. The same results were seen in intensely exercised rats. Levels of HIF-1α (A; 0.6 vs. 0.6 at 3 days, *p < 0.05; 0.8 vs. 0.7 at 14 days; 0.7 vs. 0.5 at 28 days), BDNF (B; 0.4 vs. 0.3 at 3 days; 1.5 vs. 0.7 at 14 days, **p < 0.01; 0.6 vs. 0.4 at 28 days), NGF (C; 1.1 vs. 1.9 at 3 days, **p < 0.01; 1.6 vs. 1.8 at 14 days; 0.6 vs. 0.8 at 28 days), TrkB (D; 1.0 vs. 0.9 at 3 days; 1.4 vs. 0.6 at 14 days, *p < 0.05; 0.3 vs. 0.3 at 28 days), and CREB (E; 1.4 vs. 1.2 at 3 days; 04 vs. 0.4 at 14 days; 0.6 vs. 0.5 at 28 days) were similar between exercise intensities.