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. 2020 Jun 25;14:612. doi: 10.3389/fnins.2020.00612

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Copyright © 2020 Tai, Zheng, Zhai, Cai, Xu, Yang, Jiao and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ALA ameliorates motor behavior and prevents DA neuron loss in the SN of PD rat models. ALA ameliorates apomorphine-induced rotation behavior (A) and fine motor activity in the 6-OHDA-induced rat model of PD (B). Data were expressed as the means ± SD (n = 15/group) and analyzed by one-way ANOVA. The immunohistochemical staining of TH-positive neurons in the SN. Scale bar, 500 μm (C). The number of TH-positive cells was averaged from three non-overlapped fields per slide of the SNpc region. (D) Quantification of TH-positive neurons in the SN. Data were presented as the mean ± SD (n = 3). Statistical significance: *P < 0.01 compared with the sham group; ^#P < 0.01 compared with the PD group by ANOVA.