FIGURE 6.

ALA suppresses the 6-OHDA-induced upregulation of DMT1 via IRP2 in the SN of rats and PC12 cells. Rats and cells were treated with 6-OHDA and ALA, as described in section “Materials and methods.” The iron metabolism-related protein levels of IRP2 (A,B) and DMT1 (C,D) in rat SN and PC12 cells were detected by western blot. Data were expressed as the means ± SD analyzed by one-way ANOVA (n = 3). Statistical significance: *P < 0.01 vs. sham group or control; ^##P < 0.01, ^#P < 0.05 vs. PD group or 6-OHDA.