Table 2.

Attack prevention treatment strategies for NMO/NMOSD.

Categories of immune therapies
1- Non-cell-specific interference with DNA synthesis and interference with DNA repair (cytotoxic agents)	Cyclophosphamide
2- Cell-specific interference with DNA synthesis(anti-proliferative agents)	Azathioprine Mycophenolate mofetil
3- Depletion of B-cells	Rituximab (CD20) Ocrelizumab (CD20) Ofatumumab (CD20) Inebilizumab (CD19)
4- Different mechanisms	Tocilizumab (IL-6 receptor) Satralizumab (IL-6 receptor) Eculizumab (C5 complement)
5- MS therapies that should be avoided	IFN-beta Natalizumab Fingolimod Alemtuzumab

Adapted from (102).