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. 2020 Jun 25;14:613. doi: 10.3389/fnins.2020.00613

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Copyright © 2020 Liu, Qiao, Wang, Wu, Su, Wang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MiR-224-5p increased in the cerebral cortex after MCAO and neurons after OGD. (A) TTC staining showed the cerebral infarction after MCAO. The white area was indicated as cerebral infarction. (B) The Zea Longa scores were significantly increased in 12th, 24th, and 48th hours after MCAO compared with the sham group in rats (^∗^∗P < 0.01). (C) The expression of miR-224-5p increased in 12th, 24th, and 48th hours in rats after MCAO (^∗^∗P < 0.01). (D) The bright field images of neurons after OGD. (E) The expression of miR-224-5p was significantly increased in neurons after OGD (^∗∗P < 0.01).