FIGURE 1.

a) Example trace of a GSK1016790A 100 ng·mL⁻¹ (153 nM for 15 s) mediated response. Contraction was unchanged following vehicle (6% cyclodextrin in saline) administration (b) but significantly inhibited following administration of GSK2193874 (300 mg·kg⁻¹, i.p.) (c). Data are presented as mean±sem of n=3. *: p<0.05, paired t-test comparing responses before and after antagonist/vehicle administration in the same animal.