Table 2.
Gene Ontology (GO) cellular localization analysis following differential gene expression analysis of high HERV-K expressing Hepatoblastoma vs low HERVK expressing Hepatoblastoma (Top 20 terms).
| Functional Category | Genes in list | Total genes | Enrichment FDR |
|---|---|---|---|
| Secretory granule | 80 | 946 | 9.06E−12 |
| Vesicle | 225 | 4252 | 1.39E−11 |
| Secretory vesicle | 87 | 1108 | 1.39E−11 |
| Extracellular region part | 201 | 3693 | 2.14E−11 |
| Vesicle lumen | 45 | 386 | 3.07E−11 |
| Extracellular organelle | 141 | 2326 | 6.29E−11 |
| Cytoplasmic vesicle lumen | 44 | 385 | 6.29E−11 |
| Extracellular exosome | 140 | 2300 | 6.29E−11 |
| Extracellular vesicle | 141 | 2324 | 6.29E−11 |
| Extracellular space | 188 | 3479 | 1.41E−10 |
| Secretory granule lumen | 41 | 367 | 6.38E−10 |
| Extracellular region | 228 | 4617 | 2.16E−09 |
| Cytoplasmic vesicle part | 109 | 1761 | 7.46E−09 |
| Cytoplasmic vesicle | 144 | 2625 | 2.85E−08 |
| Intracellular vesicle | 144 | 2628 | 2.88E−08 |
| Collagen-containing extracellular matrix | 38 | 425 | 1.26E−06 |
| Platelet alpha granule lumen | 14 | 70 | 1.92E−06 |
| Extracellular matrix | 44 | 551 | 2.64E−06 |
| Endomembrane system | 225 | 4988 | 6.27E−06 |
| Lysosome | 54 | 797 | 1.78E−05 |