Fig. 1.

Effects of daily supra-calvarial injections of vehicle (Veh, saline) teriparatide (10 μg/kg; TPTD10) or abaloparatide (10 or 40 μg/kg; ABL10 and ABL40, respectively) on the numbers of TRAP-positive cells and resorption cavities in calvarial bones. A: Micro-CT reconstruction of a mouse skull showing the region of histological sectioning (black box), above which the daily s.c. peptide injections were administered. B: Representative histologic cross-sections showing TRAP-stained cells (purple) occupying calvarial resorption cavities. C: Number of TRAP-positive cells per mm of calvarial length. D: Number of resorption cavities per mm of calvarial length. E: Linear regressions of TRAP-stained cells versus resorption cavities. Data represent means ± SD, n = 8/group; * P < 0.05 vs Veh control, ^{^}P < 0.05 vs TPTD10 by ordinary one-way ANOVA and Tukey's post-test.