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. 2020 Jun 25;8:520. doi: 10.3389/fcell.2020.00520

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Copyright © 2020 Richmond, van der Kloet, Vaz, Lin, Uzozie, Graham, Kobor, Mostafavi, Moerland, Lange, van Kampen, Wasserman, Engelen, Kemp and van Karnebeek.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lipidomic analysis of ALD. The univariate analysis comparing the lipid abundances between control vs. ALD, and CALD vs. non-CALD is depicted. (A) Volcano plot showing the log2 fold change between ALD and control (CRTL) samples for all of the measured metabolites within the LCMS assay, versus the -log10 transformed adjusted p-value. (B) Principal component analysis plot showing the first two principal components which can discriminate between control (blue) and ALD (orange: non-CALD, green: CALD) samples. (C) Boxplots showing the abundances of a known marker for ALD, LPC(26:0), and another lipid differentially abundant between ALD and control samples. Values are lipid abundances measured on LCMS. (D) Volcano plot showing the log2 fold change between CALD and non-CALD samples versus the -log10 transformed p-value. (E) Boxplots for lipids different between CALD and non-CALD before p-value correction. For (A,D), the lipids are colored according to their assigned class and their size corresponds to the lipid chain length. For boxplots: ^∧ represents unadjusted p-values of comparison between ALD and control, * represents unadjusted p-values of comparison between CALD and non-CALD.