Skip to main content
. Author manuscript; available in PMC: 2021 Jul 1.
Published in final edited form as: Trends Cancer. 2020 Mar 31;6(7):580–592. doi: 10.1016/j.trecan.2020.02.003

Figure 3. Major Epigenetic Regulation in Tumor Immunity.

Figure 3.

Histone post-translational modifications and DNA methylation play key roles in adaptive immune response, including dendritic cell development and T cell priming and activation. In tumor cells, histone and DNA modifications affects production of tumor antigens, silencing of anti-tumor cytokines, and induction of the PD-L1 checkpoint. Recent studies revealed the contributions of chromatin remodeling responding to cytotoxic attack in tumor cells and exhaustion phenotype in tumor infiltrating CD8 T cells. Abbreviation: PD-L1, programmed death ligand 1.